Interactions between Pb and Other Exposures Do Interactions between Pb and Other Exposures Enhance the Toxicity of Effects?
ثبت نشده
چکیده
It is possible that PB may act synergistically with other exposures to lead to adverse or toxic effects that may relate to illnesses in PGW veterans. Some have referred to a putative “toxic cocktail” (Shays, 1997), or to “cumulative health consequences of exposure to multiple risk factors” (Metcalf, 1997) including PB, vaccines, chemical weapons, pesticides, depleted uranium, infection, and smoke from oil fires.
منابع مشابه
Interactions of waterborne and dietborne Pb in rainbow trout, Oncorhynchus mykiss: Bioaccumulation, physiological responses, and chronic toxicity.
In Pb-contaminated environments, simultaneous exposure to both waterborne and dietborne Pb is likely to occur. This study examined the potential interactive effects of these two pathways in juvenile rainbow trout that were exposed to Pb in the water alone, in the diet alone, and in combination for 7 weeks. The highest waterborne Pb concentration tested (110μgL(-1)) was approximately equivalent ...
متن کاملDaphnia magna’s sense of competition: intra-specific interactions (ISI) alter life history strategies and increase metals toxicity
This work investigates whether the scale-up to multi-animal exposures that is commonly applied in genomics studies provides equivalent toxicity outcomes to single-animal experiments of standard Daphnia magna toxicity assays. Specifically, we tested the null hypothesis that intraspecific interactions (ISI) among D. magna have neither effect on the life history strategies of this species, nor imp...
متن کاملInfluence of bicarbonate and humic acid on effects of chronic waterborne lead exposure to the fathead minnow (Pimephales promelas).
Historically, the USEPA has only considered water hardness when establishing acute and chronic water quality criteria (WQC) for lead (Pb) in freshwater. Yet, recent evidence suggests that hardness may not be protective during chronic Pb exposure and that other factors (e.g., dissolved organic carbon (DOC) and alkalinity) influence toxicity. In fact, we have recently shown that Ca(2+) (as CaSO(4...
متن کاملP-158: Effect of Occupational Exposures on Male Fertility
Background: Occupational exposures do have a negative impact on the male reproductive system, but sometimes it is difficult to isolate a single insult. Workers can be exposed to a number of harmful physical, chemical and psychological factors in their working environment. During recent years, the various diseases and disorders caused by these stressors have drawn the attention of a number of re...
متن کاملDiethylnitrosamine exposure-responses for DNA damage, centrilobular cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit some non-linearities.
The exposure-responses for several effects of limited exposures to diethylnitrosamine (DEN) in the livers of male Fischer 344 rats were measured and phenobarbital promotion was used to enhance expression of initiation of carcinogenesis. Five doses ranging from a cumulative total of 0.5 to 4 mmol DEN per kg body weight were given as weekly i.p. injections for 10 weeks. This was followed by 4 wee...
متن کامل